Methanol → HCID 68901453, compound

Participants

Reaction Steps

[5-(1-Methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid (200 mg, 0.78 mmol) was suspended in Methanol (4 mL). Next, sulfuric acid (125 uL) was added and the solution was heated to reflux for 2 hours. The solution was concentrated under vacuum and the crude material was dissolved in dichloromethane, transferred to a separatory funnel and washed with sat. NaHCO3 (aq). The organic layer was dried over Na2SO4 and concentrated down. The crude product was purified by flash chromatography (0-10% Methanol/dichloromethane gradient) to afford the title compound (148 mg, 70% yield). MS m/z=271 [M+H+]+

Provenance & Evidence