6-Chloropicolinic acid → 6-chloropyridine-2-carbonyl Chloride

HRID 65527Notes

Reaction equation

HRID 65527 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[CH:4][CH:3]=1.O=S(Cl)[Cl:13]>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([Cl:13])=[O:10])[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 208126-Chloropicolinic acidHCID 24386Thionyl Chloride

Product 1

HCID 109429766-chloropyridine-2-carbonyl Chloride

Procedure

A mixture of 40 g 6-chloro-2-pyridinecarboxilic acid and 150 ml SOCl2 is refluxed 4 hrs. After removing excess SOCl2 there is obtained 44 g 6-chloro-2-pyridinecarboxylic acid chloride, m.p. 76° C.

Workup

  1. temperatureis refluxed 4 hrs
  2. customAfter removing excess SOCl2

Sources & evidence

ORD record
ord-729d01841d334557ae99ddc3e7803453
Source dataset
uspto-grants-1986_09
Patent number
US04614833

Reaction notes

Loading…