Potassium Carbonate → HCID 59320248, compound

Participants

Reaction Conditions

Reaction Steps

To a degassed (bubbled nitrogen for 15 mins) mixture of water (1 mL) and 1,4-dioxane (2 mL) was added 6-(6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-3-(1-methyl-1H-pyrazol-4-yl)-quinoline (117 mg, 0.31 mmol), vinyl boronic acid pinacol ester (59 μl, 0.35 mmol), potassium carbonate (0.93 mmol, 128 mg) and dichloro[1,1′-bis(diphenylphosphino)-ferrocene]palladium(II) dichloromethane adduct (15 mg, 0.02 mmol). The microwave tube was capped and heated in a microwave reactor (Personel Chemistry, Emrys Optimizer) at 135° C. for 1500 seconds. After such time the organic phase was concentrated on silica and purified via flash column chromatography eluting with 0-10% Methanol in dichloromethane to obtain the title compound (22 mgs, 19% yield) as a white solid. Analytical data presented in Table 2.

Provenance & Evidence