Formic Acid → HCID 59320268, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-benzene-1,2-diamine (20 mg, 0.063 mmol) in formic acid (0.5 mL) was stirred at 100° C. for 5 h. The reaction mixture was cooled to room temperature and filtered through a 0.45 micron filter. The filtrate was concentrated in vacuo. The residue was purified by preparative HPLC on Xbridge prep C18 column (5 microns, 19×150 mm) using a formic acid buffered gradient of acetonitrile in water to return the title compound as an off-white solid (15 mg, 0.046 mmol, 73% yield). Analytical data presented in Table 1.

Provenance & Evidence