3-Chloro-6-(trifluoromethyl)pyridazine → HCID 59320257, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-butanol (2 mL), 3-chloro-6-trifluoromethyl-pyridazine (0.13 mmol, 25 mg), [3-(1-methyl-1H-pyrazol-4-yl)-quinolin-6-yl]-acetic acid hydrazide (0.13 mmol, 40 mg) was heated at 120° C. for 18 hours. The solvent was then removed by blowing nitrogen, the brown residue dissolved in 1 ml of dimethylformamide and one 1 ml of methanol and purified by preparatory HPLC to return the title compound (15.8 mg, 0.04 mmol, 29%). Analytical data is presented in Table 2.

Provenance & Evidence