HCID 59320248, compound → HCID 59320222, compound

Participants

Reaction Steps

To a solution of 3-(1-methyl-1H-pyrazol-4-yl)-6-(6-vinyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-quinoline (22 mg, 0.06 mmol) in dichloromethane (5 mL) and methanol (0.5 mL) under an atmosphere of N2(g) was added 10% palladium on carbon (20 mg) and the atmosphere replaced with H2(g). After stirring vigorously for 3 hours the mixture was filtered through a pad of celite and purified via flash column chromatography (SiO2, CH2Cl2, methanol 0-10%) to return the title compound as a white solid (17 mg, 77%). Analytical data presented in Table 2.

Provenance & Evidence