Sodium hydride → HCID 59320211, compound

Participants

Reaction Conditions

Reaction Steps

6-(6-Methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-3-(1H-pyrazol-4-yl)-quinoline (65 mg, 0.19 mmol, 1 equiv) was dissolved in dimethylformamide (0.5 mL) and NaH (60% in oil, 1.2 equiv, 0.228 mmol, 9 mg) was added. The solution was stirred under nitrogen for 30 min and then 2-bromoacetamide (26 mg, 0.19 mmol, 1 equiv) was added and the solution heated at 90° C. for 18 h. The product was extracted into dichloromethane and washed with water. The organic phase was concentrated to dryness to afford the title compound (40 mg, 52% yield). Analytical data presented in Table 2.

Provenance & Evidence