Acetyl chloride → HCID 59320345, compound

Participants

Reaction Steps

To 3-(1-azetidin-3-yl-1H-pyrazol-4-yl)-6-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-quinoline (25 mg, 0.063 mmol) in dichloromethane (1 mL) was added triethylamine (9.7 uL, 0.069 mmol) followed by acetyl chloride (5.0 uL, 0.069 mmol). The mixture was stirred at room temperature overnight. The reaction was diluted with water and the product extracted into dichloromethane. The reaction was diluted with water and extracted into dichloromethane and washed with water. The filtrate was concentrated in vacuo onto silica gel and purified by flash chromatography (SiO2, CH2Cl2:CH3OH 100:0-90:10) to return the title compound (4.20 mg, 15% yield). Analytical data presented in Table 2.

Provenance & Evidence