Potassium Hydroxide → HCID 19981182, compound

HRID 65550Notes

Reaction equation

HRID 65550 reaction equation
[CH2:1]([O:8][CH:9]([C:15]([O:17]CC)=[O:16])[C:10]([O:12]CC)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>C(O)C>[CH2:1]([O:8][CH:9]([C:15]([OH:17])=[O:16])[C:10]([OH:12])=[O:11])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 290629Diethyl(benzyloxy)propanedioate

Product 1

HCID 19981182HCID 19981182, compoundYield 68.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Diethyl benzyloxymalonate (6.0 g., 22.6 mmoles) was added to an ice cold solution of potassium hydroxide (2.66 g., 47.5 mmoles) in absolute ethanol. The mixture was stirred until a homogenous mixture was obtained and stirring continued for an additional 30 minutes in a cold environment. Stirring was thereafter conducted under an atmosphere of argon at room temperature for about 16 hours. The product was filtered, washed with ethanol, and diethyl ether and then dried under vacuum to yield the dipotassium salt of benzyloxymalonic acid (4.4 g., 15.4 mmoles, 68% yield).

Workup

  1. customwas obtained
  2. stirringstirring
  3. stirringStirring
  4. waitwas thereafter conducted under an atmosphere of argon at room temperature for about 16 hours
  5. filtrationThe product was filtered
  6. washwashed with ethanol, and diethyl ether
  7. customdried under vacuum

Sources & evidence

ORD record
ord-06f4da0fde2a46689dc7a9e23d484f4d
Source dataset
uspto-grants-1978_12
Patent number
US04128425

Reaction notes

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