Triphenylphosphine → HCID 67080710, compound

Participants

Reaction Steps

Diisopropyl azodicarboxylate (806 mg, 3.75 mmol) was added at <10° C. to a solution of triphenylphosphine (983 mg, 3.75 mmol) in tetrahydrofuran (60 ml), followed by addition of a solution of (2-benzyloxycarbamoyl-ethyl)-((R)-1-hydroxymethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester (1.24 g, 2.88 mmol) in tetrahydrofuran (12 ml). The reaction mixture was stirred at <10° C. for 16 h, then concentrated. The residue was purified by chromatography (SiO2; heptane/ethyl acetate 7:3) to afford the title compound (800 mg, 68%). Light yellow oil, MS (ISP)=411.3 (M+H)+.

Provenance & Evidence