HCID 67080710, compound → HCID 67080752, compound

HRID 655520Notes

Reaction equation

HRID 655520 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12](=[O:15])[N:11](OCC2C=CC=CC=2)[CH2:10][C@H:9]1[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO>[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12](=[O:15])[NH:11][CH2:10][C@H:9]1[CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 67080710HCID 67080710, compound

Product 1

HCID 67080752HCID 67080752, compoundYield 82.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

(R)-2-Benzyl-4-benzyloxy-5-oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester (795 mg, 1.94 mmol) was dissolved in methanol (21 ml) and stirred for 16 h at 70° C. under a hydrogen pressure of 8 bar. After cooling insoluble material was removed by filtration and the filtrate concentrated, to afford the title compound (486 mg, 82%). White foam, MS (ISP)=305.3 (M+H)+.

Workup

  1. temperatureAfter cooling insoluble material
  2. customwas removed by filtration
  3. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-b1c7ecef3340401fa6ba499649a58781
Source dataset
uspto-grants-2011_12
Patent number
US08071586B2

Reaction notes

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