(R)-beta-aminophenethyl alcohol → HCID 67080722, compound

Participants

Reaction Steps

The title compound, m/e=416.4, was produced in analogy with intermediate 16, steps A to D. Thus, D-phenylglycinol was elaborated to (2-benzyloxycarbamoyl-ethyl)-((R)-2-hydroxy-1-phenyl-ethyl)-carbamic acid tert-butyl ester in step A, then cyclized in step B, leading to (R)-4-benzyloxy-5-oxo-2-phenyl-[1,4]diazepane-1-carboxylic acid tert-butyl ester. Hydrogenation in step C gave (R)-5-oxo-2-phenyl-[1,4]diazepane-1-carboxylic acid tert-butyl ester, which was alkylated with 1-(3-chloropropyl)piperidine in step D.

Provenance & Evidence