HCID 24730374, compound → HCID 67081010, compound

Participants

Reaction Steps

The title compound, m/e=444.3, was produced in analogy with intermediate 16, steps A to D. Thus, (R)-2-amino-4-phenylbutan-1-ol was elaborated to (2-benzyloxycarbamoyl-ethyl)-((R)-2-hydroxy-1-phenethyl-ethyl)-carbamic acid tert-butyl ester in step A, then cyclized in step B, leading to (R)-4-benzyloxy-5-oxo-2-phenethyl-[1,4]diazepane-1-carboxylic acid tert-butyl ester. Hydrogenation in step C gave (R)-5-oxo-2-phenethyl-[1,4]diazepane-1-carboxylic acid tert-butyl ester, which was alkylated with 1-(3-chloropropyl)piperidine in step D.

Provenance & Evidence