Hydrochloric Acid → HCID 67079895, compound

Participants

Reaction Steps

A solution of (S)-2-methyl-3-oxo-4-(3-piperidin-1-yl-propyl)-piperazine-1-carboxylic acid tert-butyl ester (1.07 g, 3.15 mmol) in 1,4-dioxane (10 ml) was treated at room temperature with hydrogen chloride solution (4 M in 1,4-dioxane, 2.4 ml, 9.6 mmol), then after 4 h the reaction mixture was partitioned between 2 M aq. sodium carbonate solution and dichloromethane. The organic layer was washed with brine, dried (MgSO4), filtered, and evaporated to afford the title compound (697 mg, 92%). Colorless gum, MS (ISP)=240.3 (M+H)+.

Provenance & Evidence