3,4-Dichlorophenyl isocyanate → HCID 59149952, compound

HRID 655552Notes

Reaction equation

HRID 655552 reaction equation
Cl.Cl.[N:3]1([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][NH:13][CH2:12][C:11]2=[O:16])[CH2:7][CH2:6][CH2:5][CH2:4]1.[Cl:17][C:18]1[CH:19]=[C:20]([N:25]=[C:26]=[O:27])[CH:21]=[CH:22][C:23]=1[Cl:24]>>[Cl:17][C:18]1[CH:19]=[C:20]([NH:25][C:26]([N:13]2[CH2:14][CH2:15][N:10]([CH2:9][CH2:8][N:3]3[CH2:7][CH2:6][CH2:5][CH2:4]3)[C:11](=[O:16])[CH2:12]2)=[O:27])[CH:21]=[CH:22][C:23]=1[Cl:24]

Participants

3

Reactant 2

HCID 76073,4-Dichlorophenyl isocyanateHCID 67080779HCID 67080779, compound2×

Product 1

HCID 59149952HCID 59149952, compoundYield 72%

Procedure

In analogy to the procedure described in Example 1, 1-(2-pyrrolidin-1-yl-ethyl)-piperazin-2-one-dihydrochloride (intermediate 12) and 3,4-dichlorophenyl isocyanate gave the title compound in 72% yield as an off-white powder. MS: 385.5 (MH+, 2Cl).

Sources & evidence

ORD record
ord-c566a7a83d124630b746c3919ec51a7c
Source dataset
uspto-grants-2011_12
Patent number
US08071586B2

Reaction notes

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