3-(Trifluoromethyl)phenyl isocyanate → HCID 59149897, compound

Participants

Reaction Conditions

Reaction Steps

3-(Trifluoromethyl)phenyl isocyanate (30 mg, 0.15 mmol) was added to a solution of (S)-3-methyl-1-(3-piperidin-1-yl-propyl)-piperazin-2-one (intermediate 20; 30 mg, 0.13 mmol) in acetonitrile (1 ml). The solution was heated at 60° C. for 15 min under microwave irradiation, then evaporated. Chromatography (SiO2; dichloromethane/methanol/25% aq. ammonia solution 90:10:0.25) produced the title compound (46 mg, 86%). Colorless gum, MS (ISP)=427.3 (M+H)+.

Provenance & Evidence