Pyridine → HCID 59149953, compound

Participants

Reaction Steps

A solution of 3-aminobiphenyl (21 mg, 0.13 mmol) and pyridine (11 mg, 0.14 mmol) in acetonitrile (0.5 ml) was added dropwise at 0° C. to a solution of bis-(trichloromethyl)-carbonate (14 mg, 47 μmol) in acetonitrile (0.5 ml). The reaction mixture was allowed to reach room temperature, then a solution of (S)-3-methyl-1-(3-piperidin-1-yl-propyl)-piperazin-2-one (30 mg, 0.13 mmol) in acetonitrile (0.5 ml) was added dropwise. After 30 min the reaction mixture was evaporated. Chromatography (SiO2; dichloromethane/methanol/25% aq. ammonia solution 90:10:0.25) produced the title compound (36 mg, 66%). Colorless gum, MS (ISP)=435.3 (M+H)+.

Provenance & Evidence