3,4-Dichlorophenyl isocyanate → HCID 59149873, compound

Participants

Reaction Steps

In analogy to the procedure described in example 5, 4-[3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-[1,4]diazepan-5-one dihydrochloride (US 2007249589, described as 4-[3-((−)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-propyl]-[1,4]diazepan-5-one dihydrochloride) and 3,4-dichlorophenyl isocyanate gave after separation with flash chromatography (silicycle SiO2, dichloromethane/methanol 95:5 to 4:1) 43% of the title compound as white solid. MS: 469.3 (MH+, 2Cl).

Provenance & Evidence