反应详情

A solution of 0.650 g (1.73 mmol) of (R)-4-(3-benzyloxy-propyl)-2-methyl-5-oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester (example 1A) in 30 ml methanol was treated with 0.065 g of Pd/C (10%) and was stirred over H2-atmosphere over night. After filtration, the solution was evaporated, reevaporated (3 times) with toluene and the solvent was removed under vacuum to give 0.485 g (98%) of the title compound as colorless oil. MS: 287.1 (MH+).

1. filtrationAfter filtration
2. customthe solution was evaporated
3. customreevaporated (3 times) with toluene
4. customthe solvent was removed under vacuum