HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride → (R)-4-[(S)-3-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-1-methoxycarbonyl-propyl]-2-methyl-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4S)-6-Azaspiro[2.5]octan-4-ol hydrochloride | HCID 44541812 | — |
| Reactant | (R)-4-((S)-1-methoxycarbonyl-3-oxo-propyl)-2-methyl-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester | HCID 86638116 | — |
| Product | (R)-4-[(S)-3-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-1-methoxycarbonyl-propyl]-2-methyl-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester | HCID 67080614 | 42% |
Reaction Steps
In analogy to the procedure described for example 58D, (R)-4-((S)-1-methoxycarbonyl-3-oxo-propyl)-2-methyl-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester and (S)-6-aza-spiro[2.5]octan-4-ol hydrochloride (intermediate 2) gave the title compound in 42% yield as yellow oil. MS: 488.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071586B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-ffef8919ec5b48b1b2bf14e2ea2c1f66 |
| Source note | uspto-grants-2011_12 |