HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenyl isocyanate → HCID 67080657, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenyl isocyanate | HCID 9483 | — |
| Reactant | HCID 67080781 | HCID 67080781 | — |
| Product | HCID 67080657 | HCID 67080657 | 39% |
Reaction Steps
In analogy to the procedure described for intermediate 58F, (R)-4-[(S)-3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-1-methoxymethyl-propyl]-2-methyl-[1,4]diazepan-5-one dihydrochloride (example 65H) and 3-(trifluoromethyl)phenyl isocyanate gave the title compound in 39% yield as orange solid. MS: 527.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071586B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-f409cb3cacc64d8e9bef8d02e3898b83 |
| Source note | uspto-grants-2011_12 |