HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dichlorophenyl isocyanate → HCID 67080677, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dichlorophenyl isocyanate | HCID 7607 | — |
| Reactant | HCID 67080781 | HCID 67080781 | — |
| Product | HCID 67080677 | HCID 67080677 | 74% |
Reaction Steps
In analogy to the procedure described for intermediate 58F, (R)-4-[(S)-3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-1-methoxymethyl-propyl]-2-methyl-[1,4]diazepan-5-one dihydrochloride (example 65H) and 3,4-dichlorophenyl isocyanate gave the title compound in 74% yield as white solid. MS: 527.2 (MH+, 2Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071586B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-9b442c2d374948b7bc8bafe740226489 |
| Source note | uspto-grants-2011_12 |