反应详情

The reaction mixture of 2-(3,4-dimethoxyphenyl)ethanol (6.0 g, 32.8 mmol) and thionyl chloride (19 g, 164 mmol) in chloroform (20 mL) was stirred at reflux for 4 h, concentrated, and partitioned between water and ethyl acetate. The organic layer was washed with NaHCO3 and brine, dried over anhydrous sodium sulfate, and concentrated to afford 4-(2-chloroethyl)-1,2-dimethoxybenzene (K) quantitatively (6.6 g).

1. temperatureat reflux for 4 h
2. concentrationconcentrated
3. custompartitioned between water and ethyl acetate
4. washThe organic layer was washed with NaHCO3 and brine
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated