HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 655631Generated: October 27, 2026
2,5-Dimethoxyaniline → n-[3-(2,5-Dimethoxy-phenylamino)-quinoxalin-2-yl]-3-fluorobenzenesulfonamide
https://huagongshe.com/reaction/655631
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,5-Dimethoxyaniline | HCID 7613 | — |
| Reactant | N-(3-chloroquinoxalin-2-yl)-3-fluorobenzenesulfonamide | HCID 57625365 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | n-[3-(2,5-Dimethoxy-phenylamino)-quinoxalin-2-yl]-3-fluorobenzenesulfonamide | HCID 16045303 | 97% |
Reaction Steps
N-(3-chloroquinoxalin-2-yl)-3-fluorobenzenesulfonamide (125 mg, 0.4 mmole) and 2,5-dimethoxyaniline (170.4 mg, 1.1 mmole) are taken in 0.5 ml of EtOH and the resulting suspension is stirred at 100° C. in an orbital shaker, overnight. The precipitate obtained is filtered and washed with EtOH then ether to afford the title compound as a dark green solid (163 mg, 97%). HPLC (max plot) 96%, rt. 4.88 min. LC/MS: (ES+): 455.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08071597B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-91967ea14f7140a1b6d0cfa9cf0bf447 |
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| Source note | uspto-grants-2011_12 |
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