反应详情

3-Methoxy-2-methoxymethoxy-5-(2-oxo-oxazolidin-3-yl)benzaldehyde (0.5 g, 1.79 mmol) was dissolved in a solvent mixture of acetic acid (5 ml) and ethanol (5 ml) and 10% palladium carbon (0.05 g) was added thereto to perform catalytic reduction at 1 atm at 50° C. for 4 hours. The reaction mixture was cooled to room temperature and filtrated by cerite. The filtrate was concentrated under reduced pressure. The residue was dissolved in acetic acid (10 ml) and 10% palladium carbon (0.05 g) was added thereto to perform catalytic reduction at 1 atm at 50° C. for 6 hours. The solvent was removed under reduced pressure to obtain 3-(3-methoxy-4-methoxymethoxy-5-methylphenyl)oxazolidin-2-one as a crude product, which was subjected to the next reaction as it was.

1. additionwas added
2. customat 50° C.
3. customfor 4 hours
4. filtrationfiltrated by cerite
5. concentrationThe filtrate was concentrated under reduced pressure
6. dissolutionThe residue was dissolved in acetic acid (10 ml)
7. addition10% palladium carbon (0.05 g) was added
8. customat 50° C.
9. customfor 6 hours
10. customThe solvent was removed under reduced pressure