Bis-(1H-imidazol-2-YL)-methanone → 7-methoxy-3,4-dihydro-1H-quinazolin-2-one

Participants

Reaction Steps

2-aminomethyl-5-methoxyaniline (1.2 g. 7.9 mmol) and carbonyl diimidazole (1.53 g, 9.5 mmol) were added to THF (100 ml) and the mixture was stirred at room temperature overnight. The insoluble matter precipitated was obtained by filtration, washed with dichloromethane and water, dried to obtain 7-methoxy-3,4-dihydro-1H-quinazolin-2-one (1.11 g) as white powder.

Provenance & Evidence