Benzylamine → HCID 66850578, compound

HRID 655689Notes

Reaction equation

HRID 655689 reaction equation
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]3)[CH:8]=2)[N:3]=1.[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:29][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]3)[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 66850468HCID 66850468, compound

Product 1

HCID 66850578HCID 66850578, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3 g of 2-amino-3-cyano-4-chloro-6-(4-methylpiperazino)quinoline and 6 mL of benzylamine are stirred at 125° C. for 3 hours. The reaction mixture is poured onto 30 mL of water. The precipitated material is filtered off, washed with 20 mL of water. After drying 2.3 g of the title compound is obtained, m.p.: 176° C.

Workup

  1. filtrationThe precipitated material is filtered off
  2. washwashed with 20 mL of water
  3. dry with materialAfter drying 2.3 g of the title compound
  4. customis obtained

Sources & evidence

ORD record
ord-8aee032f5d2a4fd79748d5b8ff5f7b13
Source dataset
uspto-grants-2011_12
Patent number
US08071601B2

Reaction notes

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