Benzylamine → HCID 66850807, compound

HRID 655711Notes

Reaction equation

HRID 655711 reaction equation
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH2:19][N:18]([CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:17][CH2:16]3)[CH:8]=2)[N:3]=1.[CH2:28]([NH2:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:35][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH2:19][N:18]([CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:17][CH2:16]3)[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 66850571HCID 66850571, compound

Product 1

HCID 66850807HCID 66850807, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

14 g of 2-amino-3-cyano-4-chloro-6-(4-benzylpiperazin-1-yl)quinoline and 28 mL of benzylamine are stirred at 125° C. for 4 hours. The reaction mixture is poured onto 100 mL of water. The precipitated material is filtered off, washed with 2×50 mL of water. After drying 8 g of the title compound is obtained, m.p.: 202° C.

Workup

  1. filtrationThe precipitated material is filtered off
  2. washwashed with 2×50 mL of water
  3. dry with materialAfter drying 8 g of the title compound
  4. customis obtained

Sources & evidence

ORD record
ord-50e11c0f15db481bb07b5d5220a07142
Source dataset
uspto-grants-2011_12
Patent number
US08071601B2

Reaction notes

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