Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 53810576 | HCID 53810576 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 54274887 | HCID 54274887 | 96% |
Reaction Steps
A solution of 405 g of methyl 2,2-dimethyl-4-(p-methoxyphenyl)-3-(p-toluenesulphonamido)butyrate in 1800 ml of dry dimethylformamide is added to a mechanically stirred suspension of 52.8 g of sodium hydride in 320 ml of the same solvent. After the reaction mixture has been heated at 80° C. for 1 hour it is cooled when 93 ml of methyl iodide is added. After an additional period of heating (under reflux) the mixture, after being cooled, is poured into plenty of water. A white crystallisate separates. After filtration and drying it melts at 132°-134° C. Yield 96%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04128548 |
|---|
| Source dataset | uspto-grants-1978_12 |
|---|
| ORD ID | ord-514973f2c1c24851a3cc2d6ede742fab |
|---|
| Source note | uspto-grants-1978_12 |
|---|
