反应详情

Ethyl (3S,4R)-4-{[(benzyloxy)carbonyl]amino}-3-ethoxypiperidine-1-carboxylate (Intermediate 23, 2.4 g, 6.87 mmol) was dissolved in methanol (150 mL) and hydrogenated over 10% palladium on carbon (1.5 g) under 50 psi of hydrogen pressure for 2 h at room temperature. The reaction mixture was then filtered through a celite bed and the filtrate was concentrated under reduced pressure to yield 1.33 g (89.62%) of Ethyl (3S,4R)-4-amino-3-ethoxypiperidine-1-carboxylate as liquid.

1. filtrationThe reaction mixture was then filtered through a celite bed
2. concentrationthe filtrate was concentrated under reduced pressure