HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate → Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate | HCID 58075022 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate | HCID 58075083 | 101.6% |
Reaction Steps
Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate (8.0 g, 0.02 mol) was dissolved in methanol (200 mL) and hydrogenated at room temperature, under 50 psi of hydrogen pressure, in the presence of palladium (2.5 g) on carbon for 2 h. The solution was then filtered and concentrated under reduced pressure to yield 3.5 g (92%) Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate as liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071605B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-e25b30d485d84329aefc171162f2844d |
| Source note | uspto-grants-2011_12 |