反应详情

温度

90 °C

To a stirred solution of 2-(1-hydroxyethyl)pyrimidin-4(3H)-one (Intermediate 50, 5 g, 35.71 mmol) in dichloroethane (200 mL), manganese dioxide (31 g, 357.1 mmol) was added. The reaction mixture was heated to 90° C. for 5 h. The reaction mixture was filtered through a celite bed and washed with dichloroethane (60 mL). The filtrate was concentrated to dryness to yield 1.6 g (32.6%) 2-acetylpyrimidin-4(3H)-one.

1. filtrationThe reaction mixture was filtered through a celite bed
2. washwashed with dichloroethane (60 mL)
3. concentrationThe filtrate was concentrated to dryness