Hydrochloric Acid → Methyl 2-chloro-4-[4-(piperidin-1-yl)pyrimidin-2-yl]-1,3-thiazole-5-carboxylate

Participants

Reaction Steps

To a stirred solution of methyl 2-amino-4-[4-(piperidin-1-yl)pyrimidin-2-yl]-1,3-thiazole-5-carboxylate (Intermediate 62, 0.070 g, 0.219 mmol) in concentrated HCl (1 mL), sodium nitrite (0.045 g, 0.658 mmol) in water (1 mL) was added drop wise at 0° C. The reaction mixture was stirred at room temperature for 30 min. The reaction mixture was cooled to 5-10° C. and basified with saturated sodium bicarbonate solution (20 mL). The aqueous layer was extracted with ethyl acetate (2×30 mL). The combined organic layer was washed with brine solution, dried and concentrated under reduced pressure to obtain methyl 2-chloro-4-[4-(piperidin-1-yl)pyrimidin-2-yl]-1,3-thiazole-5-carboxylate 0.040 g (54%).

Provenance & Evidence