反应详情

温度

50 °C

6-Chloro-9-vinylpurine (0.48 g, 3 mmol) was added to saturated ammonia/methanol (20 mL) and the mixture was heated at 50° C. for 15 h. Water was added and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, concentrated on a rotavap then subjected to silica gel column chromatography (5% methanol/methylene chloride) yielding the desired product.

1. extractionthe aqueous layer was extracted with ethyl acetate
2. dry with materialThe combined organic layers were dried over sodium sulfate
3. concentrationconcentrated on a rotavap