反应详情

温度

80 °C

Fuming nitric acid (83.3 mL) (>90%) was added slowly to a solution of 2,6-dimethyl bromobenzene (27.9 g, 150 mmol) in acetric acid (167 mL) and cooled in an ice-bath (above f.p). The mix was allowed to come to rt and later heated at 80° C. for 2 h. (HPLC showed no SM). Reaction mixture was cooled and poured into ice-water with stirring. The resulting yellow solid was filtered, washed with ice-water and dried to give 28.7 g of an yellow solid which was used as such in the next step.

1. temperaturecooled in an ice-bath (above f.p)
2. customto come to rt
3. customReaction mixture
4. temperaturewas cooled
5. filtrationThe resulting yellow solid was filtered
6. washwashed with ice-water
7. customdried