Morpholine → 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-morpholino-9H-purin-6-amine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

2-chloro-N-(4-(dimethylphosphoryl)phenyl)-9-vinyl-9H-purin-6-amine (0.05 g, 0.11 mmol) was dissolved in n-BuOH/DMSO (1.0 mL/0.2 mL) in a CEM 10 mL microwave tube and was added morpholine (95 □L, 1.1 mmol) and DIEA (96 □L, 0.55 mmol). The reaction was heated with microwave (120° C., 10 min). Solvent was removed on a rotavapor and the residue was partitioned between EtOAc/water, organic layer was separated and dried Na2SO4. The product was purified on ISCO combiFlash (12 g silica gel column, 5% MeOH/DCM) to yield the desired compound: MS [M+H]+ 559.

Herkunft & Nachweise