Benzyl chloroformate → HCID 67025956, compound

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Reaction Steps

To a stirred solution of (D4) in dry MeOH (0.2 M), NaBH4 (1.2 eq) was added and then dropwise Cbz-Cl (1.2 eq) at −65° C. The reaction was allowed to reach RT O/N, and then quenched with H2O. MeOH was concentrated under reduced pressure and EtOAc was added. The organic phase was washed with sat. aq. NaHCO3 solution, dried (Na2SO4). Evaporation of the solvent gave (D5) which was used in the next step without further purification. MS (ES) C27H25FN4O3 requires: 472. Found: 473 (M+H+).

Provenance & Evidence