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L-Prolinol → (S)-N-(2-chlorobenzyl)-2-(hydroxymethyl)pyrrolidine-1-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Prolinol | HCID 640091 | — |
| 反応物 | 1-Chloro-2-(isocyanatomethyl)benzene | HCID 2733367 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (S)-N-(2-chlorobenzyl)-2-(hydroxymethyl)pyrrolidine-1-carboxamide | HCID 59778476 | 103.1% |
反応手順
To a solution of (S)-pyrrolidin-2-ylmethanol (110 mg, 1.1 mmol) in THF (2.0 mL) was added 2-chlorobenzyl-isocyanate (167 mg, 1.0 mmol). The reaction mixture was stirred for 1 h and concentrated under reduced pressure to give (S)—N-(2-chlorobenzyl)-2-(hydroxymethyl)pyrrolidine-1-carboxamide as an oil (277 mg), which was used without further purification. LRMS (M+H+) m/z 269.0.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08071625B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-a991fe07ec824809a33d3c3ebc1dbca3 |
| 出典メモ | uspto-grants-2011_12 |