Diethyl Ether → HCID 12400373, compound

HRID 656020Notes

Reaction equation

HRID 656020 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.[CH3:9][I:10].CC[O:13][CH2:14][CH3:15]>>[I-:10].[CH3:9][N+:2]1([CH3:1])[CH:7]2[CH2:6][CH2:5][CH:4]1[CH2:3][C:14](=[O:13])[CH2:15]2

Participants

4

Reactant 3

HCID 3283Diethyl Ether2×HCID 6328Methyl iodide2×HCID 13603N-Methyl-2-piperidone

Product 1

HCID 12400373HCID 12400373, compoundYield 86.6%

Procedure

To a stirred solution of N-methylpiperidone (20.0 g, 143.7 mmol) in 150 mL of ether was added dropwise methyliodide (22.4 g, 158.1 mmol) in 100 mL of ether. The exothermic reaction was controlled by the rate of addition of methyl iodide and the mixture was stirred overnight after the addition. The white solid was filtered off by suction and dried in an oven, giving 35.0 g (86.6%) of the title compound.

Workup

  1. customThe exothermic reaction
  2. additionafter the addition
  3. filtrationThe white solid was filtered off by suction
  4. customdried in an oven

Sources & evidence

ORD record
ord-2c3bea5fa62c45c8a7df2f12d2e1994b
Source dataset
uspto-grants-2011_12
Patent number
US08071584B2

Reaction notes

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