HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 1-[(E)-2-(4-fluoro-2-nitrophenyl)ethenyl]pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-Fluoro-2-nitrotoluene | HCID 67965 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-[(E)-2-(4-fluoro-2-nitrophenyl)ethenyl]pyrrolidine | HCID 5908071 | 108.7% |
Reaction Steps
To a stirred solution of 4-fluoro-2-nitrotoluene (50.0 g, 0.327 mol) in DMF (100 mL) was added DMF-DMA (52 mL, 0.392 mol) and pyrrolidine (33 ml, 0.392 mol) in DMF (100 mL). The reaction mixture was stirred at reflux overnight and then concentrated under reduced pressure, giving 84 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071584B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-f5cab36b2d4542a5b70b48a2f53aa5e9 |
| Source note | uspto-grants-2011_12 |