関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 1-Bromo-4-fluoro-2-nitrobenzene | HCID 2773383 | — |
| 反応物 | HCID 178418507 | HCID 178418507 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | 7-bromo-4-fluoro-1H-indole | HCID 4342956 | 57% |
反応手順
A solution of 1-bromo-4-fluoro-2-nitrobenzene (3.6 g, 16.4 mmol) in THF (100 mL) was added to a solution of 1 M vinylmagnesium bromide in THF (100 mL, 100 mmol) and DME (100 mL) at −78° C. (bath temp). The reaction was stirred at −78° C. for 4 h, and saturated aqueous NH4Cl was added. The layers were separated, and the organic layer was evaporated. The crude product was purified flash chromatography, giving 2 g (57%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08071584B2 |
|---|
| 出典データセット | uspto-grants-2011_12 |
|---|
| ORD ID | ord-3850d870871d4c29b0dfd038ec0c5ee1 |
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| 出典メモ | uspto-grants-2011_12 |
|---|
