N-bromobutanimide → HCID 59332638, compound

HRID 656075Notes

Reaction equation

HRID 656075 reaction equation
C1C(=O)N([Br:8])C(=O)C1.[F:9][C:10]1[CH:18]=[CH:17][C:16]([C:19]([OH:21])=[O:20])=[C:15]2[C:11]=1[CH2:12][CH2:13][NH:14]2>C(Cl)Cl.CO>[Br:8][C:18]1[C:10]([F:9])=[C:11]2[C:15](=[C:16]([C:19]([OH:21])=[O:20])[CH:17]=1)[NH:14][CH2:13][CH2:12]2

Participants

5

Reactant 2

HCID 67184N-bromobutanimideHCID 59332581HCID 59332581, compound

Product 1

HCID 59332638HCID 59332638, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

NBS (40 mg, 0.23 mmol) was added to a solution of 4-fluoro-2,3-dihydro-1H-indole-7-carboxylic acid (36 mg, 0.14 mmol) in DCM (3 mL) and MeOH (1 mL). The reaction was stirred at room temperature overnight and filtered. The filtrate was evaporated, and the residue was purified by flash chromatography, giving the title compound.

Workup

  1. filtrationfiltered
  2. customThe filtrate was evaporated
  3. customthe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-a70f7c4aaf3b44cc890b74b5f632df03
Source dataset
uspto-grants-2011_12
Patent number
US08071584B2

Reaction notes

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