反应详情

Azetidine (0.258 mL, 3.82 mmol) was added to a solution of 5-bromo-2-thiophenesulfonyl chloride (500 mg, 1.912 mmol) in DCM (4.8 mL) in a 4 dram vial. The reaction was stirred at room temperature for 5 min. The reaction mixture was concentrated under a stream of nitrogen at 50° C. and dried under high vacuum. The residue was taken up in EtOAc (10 mL) and extracted with saturated NaHCO3 (2×2 mL). The organic layer was dried (Na2SO4), concentrated under a stream of nitrogen at 50° C., and dried under high vacuum, giving 501 mg of the title compound.

1. concentrationThe reaction mixture was concentrated under a stream of nitrogen at 50° C.
2. customdried under high vacuum
3. extractionextracted with saturated NaHCO3 (2×2 mL)
4. dry with materialThe organic layer was dried (Na2SO4)
5. concentrationconcentrated under a stream of nitrogen at 50° C.
6. customdried under high vacuum