HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azetidine → 1-[(5-Bromo-2-thienyl)methyl]azetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azetidine | HCID 10422 | — |
| Reactant | 1-[(5-Bromo-2-thienyl)methyl]pyrrolidine | HCID 59332758 | — |
| Product | 1-[(5-Bromo-2-thienyl)methyl]azetidine | HCID 59332750 | — |
Reaction Steps
The above procedure to make 1-[(5-bromo-2-thienyl)methyl]pyrrolidine was repeated except using azetidine (86 mg, 1.5 mmol) as the amine. Following the purification with the SCX column as described -[(5-bromo-2-thienyl)methyl]pyrrolidine an additional purification step on a 40 g ISCO silica column was necessary to afford the title compound (166 mg) of acceptable purity for use in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071584B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-694a762037994be086c38cf13e634772 |
| Source note | uspto-grants-2011_12 |