1-Ethyl-2-oxocyclohexaneacetic acid → 6-Ethyl-alpha,alpha-diphenyl-1,4dioxaspiro[4.5]decane-6-propanol
Reaction equation
COC(=O)CC[C:6]1(C)[CH2:15][CH2:14][CH2:13][CH2:12][C:7]21OCCO2.CO[C:20](=[O:35])[CH2:21][CH2:22][C:23]1([CH2:33][CH3:34])[CH2:32][CH2:31][CH2:30][CH2:29][C:24]21[O:28][CH2:27][CH2:26][O:25]2.C([C:38]1(CC(O)=O)[CH2:43][CH2:42][CH2:41][CH2:40][C:39]1=O)C>>[CH2:33]([C:23]1([CH2:22][CH2:21][C:20]([C:6]2[CH:7]=[CH:12][CH:13]=[CH:14][CH:15]=2)([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[OH:35])[CH2:32][CH2:31][CH2:30][CH2:29][C:24]21[O:25][CH2:26][CH2:27][O:28]2)[CH3:34]Participants
4
Procedure
In the same manner but replacing 6-methyl-1,4-dioxaspiro[4.5]decane-6-propionic acid methyl ester with an equivalent amount of 6-ethyl-1,4-dioxaspiro[4.5]decane-6-propionic acid methyl ester, described in Example 7, 1-ethyl-2-oxocyclohexaneacetic acid, identical to the product of the same name in Example 5, is obtained via the respective intermediates, 6-ethyl-α,α-diphenyl-1,4dioxaspiro[4.5]decane-6-propanol, νmaxCHCl3 3450 cm, nmr (CDCl3) δ 0.75 (t, J = 7, 3H), 3.85 (s, 4H), 7.2-7.6 (m, 10H) and 2-ethyl-2-(3,3-diphenylallyl)cyclohexanone, νmaxCHCl33 1740 cm-1.
Sources & evidence
- ORD record
- ord-0d097b5bb6e44ee3ba93e5a28faa80e3
- Source dataset
- uspto-grants-1978_12
- Patent number
- US04128560
Reaction notes
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