Hydrazine → HCID 86638997, compound

Participants

Reaction Steps

A mixture of thiobenzoic acid S-((6R,8R)-8-tert-butoxycarbonylamino-1,4-dioxa-spiro[4.5]dec-6-yl) ester+(6S,8S) diastereomer (695 mg, 1.77 mmol) and hydrazine (80% aq. solution, 0.10 ml, 2.65 mmol) in 7 ml of dichloromethane was stirred for 24 hours. The mixture was diluted with dichloromethane and washed with 1M aqueous HCl, dried and stripped of the solvent to obtain the title compound (490 mg, 95% yield) as yellow-gray oil.

Provenance & Evidence