HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → Methyl 6-bromo-3-methoxypyridine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | Methyl 6-bromo-3-hydroxypicolinate | HCID 22175135 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Methyl 6-bromo-3-methoxypyridine-2-carboxylate | HCID 70700803 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A solution of diazomethane in diethyl ether (about 0.4 M) is added in excess to a solution of 2.3 mmol of methyl 6-bromo-3-hydroxypyridine-2-carboxylate [321601-48-3] in 30 ml of methanol at 0° C. The mixture is stirred at 0° C. for 2 hours, then quenched with magnesium sulphate, filtered and evaporated. The crude title compound is identified by means of the Rf.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071651B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-1ca5ff9f07c24d21bca5e246b7fb6232 |
| Source note | uspto-grants-2011_12 |