反应详情

A solution of 1,2,3,3a,4,5-hexahydro-3a-methyl-6H-pyrido[3,2,1-jk]carbazol-6-one (0.5 g), described in Example 40, in ethanol (10 ml) and 10% sodium hydroxide solution (10 ml) is heated at reflux for 3 hr. The mixture is concentrated, diluted with water and washed with ether. The aqueous phase is rendered acidic with conc. HCl and extracted with chloroform. Concentration of the chloroform extract yields the title compound as a solid, mp 204°-206° C., identical to the product of Example 69.

1. temperatureat reflux for 3 hr
2. concentrationThe mixture is concentrated
3. additiondiluted with water
4. washwashed with ether
5. extractionextracted with chloroform
6. extractionConcentration of the chloroform extract