反应详情

To an ice cold suspension of aluminium chloride (126 mg) in ether (1.5 ml) was added a suspension of lithium aluminium hydride (55 mg) in ether (1.5 ml), followed by stirring for 5 min. A solution of 5-cyanoindole (103 mg) in ether (5 ml) was added dropwise thereto. The mixture was stirred at room temperature for 6 hours, followed by adding aqueous Rochel solution thereto and then stirring for 5 hours. The resulting mixture was basified with 1M aqueous sodium hydroxide solution, extracted twice with ethyl acetate (50 ml), washed with saturated aqueous sodium chlroride solution, dried over magnesium sulfate and then filtered to yield (1H-indol-5-yl)methylamine (93 mg, 88%).

1. additionwas added
2. stirringThe mixture was stirred at room temperature for 6 hours
3. additionby adding aqueous Rochel solution
4. stirringstirring for 5 hours
5. extractionextracted twice with ethyl acetate (50 ml)
6. washwashed with saturated aqueous sodium chlroride solution
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered