(1H-indol-5-yl)methanamine → HCID 59088005, compound

HRID 656260Notes

Reaction equation

HRID 656260 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][NH2:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[CH2:12]([N:20]=[C:21]=[O:22])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][NH:11][C:21]([NH:20][CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:22])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 54791(1H-indol-5-yl)methanamineHCID 160602Phenethyl isocyanate

Product 1

HCID 59088005HCID 59088005, compoundYield 76%

Procedure

(1H-indol-5-yl)methylamine (12.5 mg) was reacted with phenethylisocyanate (30 μl) according to the similar procedure as described in step 2 of Example 1, to give 1-(1H-indol-5-ylmethyl)-3-phenethylurea (1-6) (19 mg, 76%).

Sources & evidence

ORD record
ord-61aeb33b6d2843d19f2fbacedff9e2f1
Source dataset
uspto-grants-2011_12
Patent number
US08071650B2

Reaction notes

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